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Omega-3 used to treat bipolar disorder?

June 9, 2011
by News release
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Indianapolis — A diet rich in omega 3 fatty acids may help the treatment and prevention of bipolar disorder and may also help with alcoholism, according to a new study. The findings are published in the journal Translational Psychiatry.

The study used mice used with "characteristic bipolar symptoms," including being depressed and, when subjected to stress, becoming manic. The fatty acid DHA, one of the main active ingredients in fish oil, "normalized their behavior," according to lead author Dr. Alexander B. Niculescu, an associate professor of psychiatry Indiana University School of Medicine in Indianapolis.

"The mice that were given DHA normalized their behavior, they are not depressed and when subjected to stress, they do not become manic," Niculescu said. "When we looked into their brains, using comprehensive gene expression studies, we were surprised to see that genes that are known targets of psychiatric medications were modulated and normalized by DHA."

An unexpected finding was that mice given DHA also showed a reduced desire for alcohol.

"These bipolar mice, like some bipolar patients, love alcohol. The mice on DHA drank much less; it curtailed their alcohol abusive behavior," Niculescu said. "There is now substantial evidence at the molecular level that omega-3 fatty acids work on the brain in ways similar to psychiatric drugs."

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